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1

Chemoselective, accelerated and stereoselective aza-Michael addition of amines to N-phenylmaleimide by using TMEDA based receptors

Yuefeng Bi, Laëtitia Bailly, Francis Marsais, Vincent Levacher, Cyril Papamicaël, Georges Dupas

Journal:

Tetrahedron: Asymmetry

Year:

2004

Language:

english

File:

PDF, 296 KB

english, 2004

2

Synthesis of Sulfonic Acid Derivatives by Oxidative Deprotection of Thiols Using tert -Butyl Hypochlorite

Joyard, Yoann, Papamicaël, Cyril, Bohn, Pierre, Bischoff, Laurent

Journal:

Organic Letters

Year:

2013

Language:

english

File:

PDF, 374 KB

english, 2013

3

Palladium-Catalyzed Carbonylation of (Hetero)Aryl, Alkenyl and Allyl Halides by Means of N- Hydroxysuccinimidyl Formate as CO Surrogate

Barré, Anaïs, Ţînţaş, Mihaela-Liliana, Alix, Florent, Gembus, Vincent, Papamicaël, Cyril, Levacher, Vincent

Journal:

Journal of Organic Chemistry

Year:

2015

Language:

english

File:

PDF, 7.95 MB

english, 2015

4

Rational design of carbamate-based dual binding site and central AChE inhibitors by a “biooxidisable” prodrug approach: Synthesis, in vitro evaluation and docking studies

Ţînţaş, Mihaela-Liliana, Gembus, Vincent, Alix, Florent, Barré, Anaïs, Coadou, Gaël, Truong, Lina, Sebban, Muriel, Papamicaël, Cyril, Oulyadi, Hassan, Levacher, Vincent

Journal:

European Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 1022 KB

english, 2018

5

ChemInform Abstract: Some Applications of the Regioselective Lithiation of α-Carbolines.

C. PAPAMICAEL, G. DUPAS, G. QUEGUINER, J. BOURGUIGNON

Journal:

Year:

1998

File:

PDF, 40 KB

1998

6

ChemInform Abstract: Modular Synthesis of Benzene-Centered Porphyrin Trimers and a Dendritic Porphyrin Hexamer.

O. MONGIN, C. PAPAMICAEL, N. HOYLER, A. GOSSAUER

Journal:

Year:

1998

File:

PDF, 25 KB

1998

7

ChemInform Abstract: Regioselective Metalation of γ-Carbolines.

Cyril Papamicael, Georges Dupas, Guy Queguiner, Jean Bourguignon

Journal:

Year:

1999

File:

PDF, 39 KB

1999

8

ChemInform Abstract: A Convenient Synthesis of 3,4-Difunctionalized δ-Carbolines.

Cyril Papamicael, Guy Queguiner, Jean Bourguignon, Georges Dupas

Journal:

Year:

2001

File:

PDF, 38 KB

2001

9

ortho-Lithiation of S-tert-Butyl-S-phenylsulfoximines. New Route to Enantiopure Sulfinamides via a De-tert-Butylation Reaction.

Stephane Gaillard, Cyril Papamicael, Georges Dupas, Francis Marsais, Vincent Levacher

Journal:

Year:

2005

File:

PDF, 37 KB

2005

10

Single-Step Preparation of a 4-(Dimethylamino)pyridine Analogue Bearing a Sulfoxide as New Chiral Inducer. Preliminary Evaluation as Nucleophilic Catalyst.

Thomas Poisson, Mael Penhoat, Cyril Papamicael, Georges Dupas, Vincent Dalla, Francis Marsais, Vincent Levacher

Journal:

Year:

2006

File:

PDF, 15 KB

2006

11

A rapid synthesis of new benzene-centered porphyrin trimers

Cyril A. Papamicaël, Olivier Mongin, Albert Gossauer

Journal:

Journal of Heterocyclic Chemistry

Year:

2007

Language:

english

File:

PDF, 465 KB

english, 2007

12

Synthesis and study of a heterocyclic receptor designed for carboxylic acids

Gregory Moore, Cyril Papamicaël, Vincent Levacher, Jean Bourguignon, Georges Dupas

Journal:

Year:

2004

Language:

english

File:

PDF, 510 KB

english, 2004

13

ortho-Lithiation of S-tert-butyl-S-phenylsulfoximines. New route to enantiopure sulfinamides via a de-tert-butylation reaction

Stéphane Gaillard, Cyril Papamicaël, Georges Dupas, Francis Marsais, Vincent Levacher

Journal:

Year:

2005

Language:

english

File:

PDF, 428 KB

english, 2005

14

Preparation of axially chiral quinolinium salts related to NAD+ models: new investigations of these biomimetic models as ‘chiral amide-transferring agents’

Stéphane Leleu, Cyril Papamicaël, Francis Marsais, Georges Dupas, Vincent Levacher

Journal:

Tetrahedron: Asymmetry

Year:

2004

Language:

english

File:

PDF, 389 KB

english, 2004

15

New development of Meyers’ methodology: stereoselective preparation of an axially chiral 5,7-fused bicyclic lactam related to circumdatins/benzomalvins and asperlicins

Maël Penhoat, Pierre Bohn, Georges Dupas, Cyril Papamicaël, Francis Marsais, Vincent Levacher

Journal:

Tetrahedron: Asymmetry

Year:

2006

Language:

english

File:

PDF, 161 KB

english, 2006

16

Meyers’ bicyclic lactam formation under mild and highly stereoselective conditions

Maël Penhoat, Stephane Leleu, Georges Dupas, Cyril Papamicaël, Francis Marsais, Vincent Levacher

Journal:

Tetrahedron Letters

Year:

2005

Language:

english

File:

PDF, 147 KB

english, 2005

17

A convenient synthesis of 3,4-difunctionalized δ-carbolines

Cyril Papamicaël, Guy Quéguiner, Jean Bourguignon, Georges Dupas

Journal:

Year:

2001

Language:

english

File:

PDF, 167 KB

english, 2001

18

Study of the lithiation of 3-substituted α-carbolines a new route to 3,4-disubstituted derivatives

Cyril Papamicaël, Georges Dupas, Jean Bourguignon, Guy Quéguiner

Journal:

Tetrahedron Letters

Year:

1994

Language:

english

File:

PDF, 329 KB

english, 1994

19

Synthesis ofC1- andC3ν-Symmetric Porphyrin Trimers Based on Triphenylmethane Cores

Cyril A. Papamicaël, Olivier Mongin, Albert Gossauer

Journal:

Monatshefte für Chemie - Chemical Monthly

Year:

2007

Language:

english

File:

PDF, 259 KB

english, 2007

20

Structural basis for the broad-spectrum inhibition of metallo-β-lactamases by thiols

Karsisiotis, Andreas I., Damblon, Christian, Lassaux, Patricia, Papamicael, Cyril, Roberts, Gordon C. K., Galleni, Moreno, Dideberg, Otto, Liénard, Benoît M. R., Garau, Gianpiero, Horsfall, Louise

Journal:

Organic & Biomolecular Chemistry

Year:

2008

Language:

english

File:

PDF, 744 KB

english, 2008

21

Three-dimensional Structure of FEZ-1, a Monomeric Subclass B3 Metallo-β-lactamase from Fluoribacter gormanii, in Native Form and in Complex with d-Captopril

I Garcı́a-Sáez, P.S Mercuri, C Papamicael, R Kahn, J.M Frère, M Galleni, G.M Rossolini, O Dideberg

Journal:

Journal of Molecular Biology

Year:

2003

Language:

english

File:

PDF, 1.28 MB

english, 2003

22

Rational design of central selective acetylcholinesterase inhibitors by means of a “bio-oxidisable prodrug” strategy

Bohn, Pierre, Le Fur, Nicolas, Hagues, Guillaume, Costentin, Jean, Torquet, Nicolas, Papamicaël, Cyril, Marsais, Francis, Levacher, Vincent

Journal:

Organic & Biomolecular Chemistry

Year:

2009

Language:

english

File:

PDF, 233 KB

english, 2009

23

Solid phase synthesis of a redox delivery system with the aim of targeting peptides into the brain

Patteux, Claudine, Foucout, Lénaïg, Bohn, Pierre, Dupas, Georges, Leprince, Jérôme, Tonon, Marie-Christine, Dehouck, Bénédicte, Marsais, Francis, Papamicaël, Cyril, Levacher, Vincent

Journal:

Organic & Biomolecular Chemistry

Year:

2006

Language:

english

File:

PDF, 455 KB

english, 2006

24

Modular Synthesis of Benzene-Centered Porphyrin Trimers and a Dendritic Porphyrin Hexamer †

Mongin, Olivier, Papamicaël, Cyril, Hoyler, Nicolas, Gossauer, Albert

Journal:

Journal of Organic Chemistry

Year:

1998

Language:

english

File:

PDF, 197 KB

english, 1998

25

Amine Capture Strategy for Peptide Bond Formation by Means of Quinolinium Thioester Salts

Leleu, Stéphane, Penhoat, Maël, Bouet, Alexis, Dupas, Georges, Papamicaël, Cyril, Marsais, Francis, Levacher, Vincent

Journal:

Journal of the American Chemical Society

Year:

2005

Language:

english

File:

PDF, 87 KB

english, 2005

26

New developments in redox chemical delivery systems by means of 1,4-dihydroquinoline-based targetor: Application to galantamine delivery to the brain

Ţînţaş, Mihaela-Liliana, Foucout, Lénaïg, Petit, Sylvain, Oudeyer, Sylvain, Gourand, Fabienne, Barré, Louisa, Papamicaël, Cyril, Levacher, Vincent

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 812 KB

english, 2014

27

Synthesis and biological evaluation of a novel 99mTc labeled 2-nitroimidazole derivative as a potential agent for imaging tumor hypoxia

Joyard, Yoann, Joncour, Vadim Le, Castel, Hélène, Diouf, Chérif Bounana, Bischoff, Laurent, Papamicaël, Cyril, Levacher, Vincent, Vera, Pierre, Bohn, Pierre

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 771 KB

english, 2013

28

Synthesis of new 18F-radiolabeled silicon-based nitroimidazole compounds

Joyard, Yoann, Azzouz, Rabah, Bischoff, Laurent, Papamicaël, Cyril, Labar, Daniel, Bol, Anne, Bol, Vanessa, Vera, Pierre, Grégoire, Vincent, Levacher, Vincent, Bohn, Pierre

Journal:

Bioorganic & Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 838 KB

english, 2013

29

Selective Inhibition of Factor Inhibiting Hypoxia-Inducible Factor

McDonough, Michael A., McNeill, Luke A., Tilliet, Melanie, Papamicaël, Cyril A., Chen, Qiu-Yun, Banerji, Biswadip, Hewitson, Kirsty S., Schofield, Christopher J.

Journal:

Journal of the American Chemical Society

Year:

2005

Language:

english

File:

PDF, 114 KB

english, 2005

30

Investigations of Electronic Energy Transfer Dynamics in Multiporphyrin Arrays

Brodard, Pierre, Matzinger, Stephan, Vauthey, Eric, Mongin, Olivier, Papamicaël, Cyril, Gossauer, Albert

Journal:

Journal of Physical Chemistry A

Year:

1999

Language:

english

File:

PDF, 353 KB

english, 1999

31

The Inhibitor Thiomandelic Acid Binds to Both Metal Ions in Metallo- -lactamase and Induces Positive Cooperativity in Metal Binding

Damblon, C., Jensen, M., Ababou, A., Barsukov, I., Papamicael, C., Schofield, C. J., Olsen, L., Bauer, R., Roberts, G. C. K.

Journal:

Journal of Biological Chemistry

Year:

2003

Language:

english

File:

PDF, 1.00 MB

english, 2003

32

The 1.5-A Structure of Chryseobacterium meningosepticum Zinc -Lactamase in Complex with the Inhibitor, D-Captopril

Garcia-Saez, I., Hopkins, J., Papamicael, C., Franceschini, N., Amicosante, G., Rossolini, G. M., Galleni, M., Frere, J.-M., Dideberg, O.

Journal:

Journal of Biological Chemistry

Year:

2003

Language:

english

File:

PDF, 830 KB

english, 2003

33

Dihydroquinoline Carbamate Derivatives as “Bio-oxidizable” Prodrugs for Brain Delivery of Acetylcholinesterase Inhibitors: [ 11 C] Radiosynthesis and Biological Evaluation

Bohn, Pierre, Gourand, Fabienne, Papamicaël, Cyril, Ibazizène, Méziane, Dhilly, Martine, Gembus, Vincent, Alix, Florent, Ţînţaş, Mihaela-Liliana, Marsais, Francis, Barré, Louisa, Levacher, Vincent

Journal:

ACS Chemical Neuroscience

Year:

2015

Language:

english

File:

PDF, 1.30 MB

english, 2015

34

Preparation of 1,4-Dihydroquinolines Bearing a Chiral Sulfoxide Group: New Highly Enantioselective Recyclable NADH Mimics

Gaillard, Stéphane, Papamicaël, Cyril, Marsais, Francis, Dupas, Georges, Levacher, Vincent

Journal:

Year:

2005

Language:

english

File:

PDF, 97 KB

english, 2005

35

Single-Step Preparation of a 4-(Dimethylamino)pyridine Analogue Bearing a Sulfoxide as New Chiral Inducer. Preliminary Evaluation as Nucleophilic Catalyst

Poisson, Thomas, Penhoat, Maël, Papamicaël, Cyril, Dupas, Georges, Dalla, Vincent, Marsais, Francis, Levacher, Vincent

Journal:

Year:

2005

Language:

english

File:

PDF, 90 KB

english, 2005

36

DMAP-Organocatalyzed O -Silyl- O -(or C -)-Benzoyl Interconversions by Means of Benzoyl Fluoride

Poisson, Thomas, Dalla, Vincent, Papamicaël, Cyril, Dupas, Georges, Marsais, Francis, Levacher, Vincent

Journal:

Year:

2007

Language:

english

File:

PDF, 132 KB

english, 2007

37

ChemInform Abstract: Palladium-Catalyzed Carbonylation of (Hetero)Aryl, Alkenyl and Allyl Halides by Means of N-Hydroxysuccinimidyl Formate as CO Surrogate.

Barre, Anais, Tintas, Mihaela-Liliana, Alix, Florent, Gembus, Vincent, Papamicael, Cyril, Levacher, Vincent

Journal:

Year:

2015

File:

PDF, 98 KB

2015

38

ChemInform Abstract: Synthesis of Sulfonic Acid Derivatives by Oxidative Deprotection of Thiols Using tert-Butyl Hypochlorite.

Joyard, Yoann, Papamicael, Cyril, Bohn, Pierre, Bischoff, Laurent

Journal:

Year:

2013

File:

PDF, 33 KB

2013

39

NMR Study of the Amide Bond-formation Using a Heterocyclic Amine and Acid Receptor

Condamine, Eric, Moore, Grégory, Marsais, Francis, Dupas, Georges, Papamicaël, Cyril, Levacher, Vincent

Journal:

Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 816 KB

english, 2005

40

A Technique to Determine the Thermal Stability of Uracil and Uracil Derivatives in a Molecular Beam

Maddern, Todd M., Jamier, Vincent, Brunton, Jessica R., Brunger, Michael J., Papamicaël, Cyril, Smith, Suzanne V., Buckman, Stephen J.

Journal:

International Journal of Mass Spectrometry

Year:

2016

Language:

english

File:

PDF, 1.30 MB

english, 2016

41

Exploring the synthesis and metal complexation behavior of mono and bis substituted hexaazamacrocyclic cage derivatives

Jamier, Vincent, Mume, Eskender, Papamicaël, Cyril, Smith, Suzanne V.

Journal:

Inorganic Chemistry Communications

Year:

2017

Language:

english

File:

PDF, 645 KB

english, 2017

42

Donepezil-based Central Acetylcholinesterase Inhibitors by means of a “Bio-oxidizable” Prodrug Strategy: Design, Synthesis and in vitro Biological Evaluation.

Peauger, Ludovic, Azzouz, Rabah, Gembus, Vincent, Tintas, Mihaela-Liliana, Sopková-de Oliveira Santos, Jana, Bohn, Pierre, Papamicaël, Cyril, Levacher, Vincent

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 1.14 MB

english, 2017

43

Delivering FLT to the Central Nervous System by Means of a Promising Targeting System: Synthesis, [11C]Radiosynthesis and in Vivo Evaluation.

Gourand, Fabienne, Ţînţaş, Mihaela-Liliana, Henry, Axelle, Ibazizène, Méziane, Dhilly, Martine, Fillesoye, Fabien, Papamicaël, Cyril, Levacher, Vincent, Barre, Louisa

Journal:

ACS Chemical Neuroscience

Year:

2017

Language:

english

File:

PDF, 1.08 MB

english, 2017

44

Novel donepezil-like N -benzylpyridinium salt derivatives as AChE inhibitors and their corresponding dihydropyridine “bio-oxidizable” prodrugs: Synthesis, biological evaluation and structure-activity relationship

Azzouz, Rabah, Peauger, Ludovic, Gembus, Vincent, Ţînţaş, Mihaela-Liliana, Sopková-de Oliveira Santos, Jana, Papamicaël, Cyril, Levacher, Vincent

Journal:

European Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 1.97 MB

english, 2017

45

Access to highly enantioenriched donepezil-like 1,4-dihydropyridines as promising anti-Alzheimer prodrug candidates via enantioselective Tsuji allylation and organocatalytic aza-ene-type domino reactions

TINTAS, Mihaela-Liliana, Azzouz, Rabah, Peauger, Ludovic, GEMBUS, Vincent, Petit, Emilie, Bailly, Laetitia, Papamicaël, Cyril, Levacher, Vincent

Journal:

Journal of Organic Chemistry

Year:

2018

Language:

english

File:

PDF, 562 KB

english, 2018

46

Dihydroquinoline Carbamate DQS1-02 as a Prodrug of a Potent Acetylcholinesterase Inhibitor for Alzheimer’s Disease Therapy: Multigram-Scale Synthesis, Mechanism Investigations, in Vitro Safety Pharmacology, and Preliminary in Vivo Toxicology Profile

Alix, Florent, Gembus, Vincent, Coquet, Laurent, Hubert-Roux, Marie, Chan, Philippe, Truong, Lina, Sebban, Muriel, Coadou, Gaël, Oulyadi, Hassan, Papamicaël, Cyril, Levacher, Vincent

Journal:

Year:

2018

Language:

english

File:

PDF, 1.61 MB

english, 2018

47

Chemical Delivery System of MIBG to the Central Nervous System: Synthesis, 11C-Radiosynthesis and in Vivo Evaluation

Gourand, Fabienne, Patin, Delphine, Henry, Axelle, Ibazizène, Méziane, Dhilly, Martine, Fillesoye, Fabien, Tirel, Olivier, TINTAS, Mihaela-Liliana, Papamicaël, Cyril, Levacher, Vincent, Barre, Louisa

Journal:

ACS Medicinal Chemistry Letters

Year:

2019

Language:

english

File:

PDF, 354 KB

english, 2019

48

Design, Synthesis, and In Vitro Biological Activities of a Bio-Oxidizable Prodrug to Deliver Both ChEs and DYRK1A Inhibitors for AD Therapy

Barré, Anaïs, Azzouz, Rabah, Gembus, Vincent, Papamicaël, Cyril, Levacher, Vincent

Journal:

Year:

2019

File:

PDF, 1.55 MB

2019

49

Design, Synthesis, and In Vitro Biological Activities of a Bio-Oxidizable Prodrug to Deliver Both ChEs and DYRK1A Inhibitors for AD Therapy

Barré, Anaïs, Azzouz, Rabah, Gembus, Vincent, Papamicaël, Cyril, Levacher, Vincent

Journal:

Year:

2019

Language:

english

File:

PDF, 1.55 MB

english, 2019

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